The suppression of big WT1 isoform-mediated transcriptional activation by Ex4a(+) WT1 is likely to be prolonged to other direct transcriptional targets too as Bcl-xL and Bcl-2. Considering that several other genes liable for anti-apoptosis such as BFL-1 and c-myc have already been also recognized as immediate transcriptional targets of important WT1 isoforms [16, 17], Ex4a(+)WT1-induced apoptosis


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