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The present study confirmed that the WT1 gene was alternatively spliced at Ex4a to produce isoforms with opposing roles in apoptosis, anti-apoptotic isoforms (main WT1 isoforms) and pro-apoptotic isoform (truncated Ex4a(+)WT1 isoform). Many other genes concerned in apoptosis, this kind of as p53 [39], Survivin [40], Fas [41], and caspase-9 [42] are known to make isoforms with opposing roles in adv
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As an example, alternatively spliced truncated p53 isoform termed p47 inhibits wild-type p53-induced apoptosis by means of suppression of wild-type p53-mediated transcriptional action [39]. Truncated Survivin-2a isoform attenuates the anti-apoptotic exercise of wild-type Survivin, possibly through immediate conversation with wild-type Survivin [40]. These examples, collectively with our existing s